Celiac disease
chronic digestive disease with both a environmental
and genetic component that damage small intestinal mucosal.
Celiac disease: 1% of American population
:cannot tolerate gluten.Gluten have two major protein types: gliadins, glutenins.
They have resistant to complete digest by human intestine enzymes.
They eat food containing gluten, their immune system over activity cause inflammation:
destroy villi ,malnutrition
Other symptoms: fatigue, anemia, arthritis, osteoporosis , irritability, constipation, miscarriage and, dermatitis.
CD is associated with the major histocompatibility complex (MHC) class II alleles: HLA-DQ2,HLA-DQ8
Only effective treatment :Gluten- free diet.
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