Botulinum
Toxin
Botulinum toxin is among the most deadly naturally occurring Neurotoxins, produced by the naturally occurring Clostridium botulinum and causing the fatal disease Botulism.
Botulinum toxin is a protein consisting of seven related A-B
toxins. Each botulinum toxin molecule is comprised of a heavy chain and of a
light chain, connected by a disulfide bond. Botulinum toxin is a "blocking agent"
preventing the release of certain neurotransmitters, specifically
Acetylcholine, from the endings of the motor nerves.
Botulinum toxin has a light chain and a heavy chain, each of
which contributes to the toxicity. The heavy chain allows the protein to bind
to and enter a neuron. After the heavy chain allows entry, the light chain acts
like a protease and cleaves proteins that would normally allow neurotransmitters to leave the cell. This is essentially a disruption of
exocytosis or the release of neurotransmitters.
The blocked neurotransmitter, Acetylcholine, normally transmits a nerve impulse to a muscle,
signaling the muscle to contract. By blocking this neurotransmitter, botulinum toxin
causes its characteristic flaccid paralysis
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